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Mutational dynamics across VOCs in International travellers and Community transmission underscores importance of Spike-ACE2 interaction


  • The mutational landscape of 1567 international travellers and community transmission were characterized across VOCs in India
  • Mutations in LD for VOCs demonstrated differentially altered binding affinity and electrostatic interactions of Spike-ACE2.•
  • Altered Spike-ACE2 affinity among VOCs predicted sudden takeover of Delta over Alpha and BA.2 over BA.1 in India.

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