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Mutational dynamics across VOCs in International travellers and Community transmission underscores importance of Spike-ACE2 interaction

Highlights

The mutational landscape of 1567 international travellers and community transmission were characterized across VOCs in India
Mutations in LD for VOCs demonstrated differentially altered binding affinity and electrostatic interactions of Spike-ACE2.•
Altered Spike-ACE2 affinity among VOCs predicted sudden takeover of Delta over Alpha and BA.2 over BA.1 in India.

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